Improved mood and behavior during treatment with a mineral-vitamin supplement: an open-label case series of children.
Kaplan BJ, Fisher JE, Crawford SG, Field CJ, Kolb B.
Journal of Child and Adolescent Psychopharmacology. 2004 Spring;14(1):115-22.

 

ABSTRACT:

A group of scientists from three Alberta universities and the Alberta Children’s Hospital published the results of 11 unselected children with mood and behavior problems. The diagnoses of the children included attention deficit hyperactivity disorder (ADHD), bipolar disorder, oppositional defiant disorder (ODD), obsessive-compulsive disorder (OCD), Asperger syndrome, generalized anxiety disorder (GAD), Prader-Willi Syndrome depression, anxiety, and rage. The children were assessed for a minimum of 8 weeks on an adult dose of EMPowerplus, which was well-tolerated. Outcomes were measured with the Young Mania Rating Scale (YMRS), the Youth Outcome Questionnaire (YOQ), and the Child Behavior Checklist (CBCL).

Results: For all 9 children who completed the trial, the micronutrient treatment was clinically beneficial, and all effect sizes were large (>.8). Improvement was significant on the YOQ (measuring children’s mood, physical symptoms, self-harm behavior, interpersonal relationship problems, social problems, and attention problems), the YMRS (measuring symptoms such as irritability and disruptive aggressive behaviors), and 7 of the 8 CBCL scales (withdrawn behavior, anxious/depressed mood, social problems, thought problems, attention problems, delinquent behavior, and aggressive behavior).

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