Research on the Empowerplus Formula Since 1996, scientific researchers and doctors in clinical practice have been studying the effects of EMPowerplus™ on disorders such as bipolar disorder and depression. Results have been very encouraging and significant. Dr. Bonnie Kaplan, a respected behavioral research scientist and one of the principal researchers on several of the published studies says, “If substantiated in controlled trials, the normalization of the mentally ill via nutrient supplementation would be the most significant breakthrough in the field of mental illness since the beginning of time.” All Research

Feasibility of a Nutritional Supplement as Treatment for Pediatric Bipolar Spectrum Disorders Frazier E, Fristad M, Arnold E The Journal of Alternative and Complementary Medicine July 2012, 18(7): 678-685. doi:10.1089/acm.2011.0270 Summary /  Full Text

Shaken but unstirred? Effects of micronutrients on stress and trauma after an earthquake: RCT evidence comparing formulas and doses Rucklidge J, Andridge R, Gorman B, Blampied N, Gordon H, Boggis A Human Psychopharmacology: Clinical and Experimental (2012) DOI: 10.1002/hup.2246 Summary /  Full Text

Post-Earthquake Psychological Functioning in Adults with Attention-Deficit / Hyperactivity Disorder: Positive Effects of Micronutrients on Resilience Rucklidge J, Blampied N New Zealand Journal of Psychology Volume 40, No. 4, 2011, Pages 51-57, ISSN: 1179-7924 Summary /  Full Text

Can Micronutrients Improve Neurocognitive Functioning in Adults with ADHD and Severe Mood Dysregulation? A Pilot Study. Rucklidge J, Johnstone J, Harrison R The Journal of Alternative and Complementary Medicine December 2011, 17(12) 2011, pp. 1125-1131 Summary /  Full Text

Micronutrients reduce stress and anxiety following a 7.1 earthquake in adults with Attention-Deficit/Hyperactivity Disorder. Rucklidge J, Johnstone J, Harrison R, Boggis A Psychiatry Research Volume 189, Issue 2 , Pages 281-287, 30 September 2011 Summary /  Full Text

Systematic review of safety and tolerability of a complex micronutrient formula used in mental health. Simpson JS, Crawford SG, Goldstein ET, Field C, Burgess E, Kaplan BJ BMC Psychiatry 2011 Apr 18;11:62 Summary /  Full Text

Effect of micronutrients on behavior and mood in adults with ADHD: evidence from an 8-week open label trial with natural extension. Rucklidge J, Taylor M, Whitehead K Journal of Attention Disorders 2011 Jan;15(1):79-91 Summary /  Full Text

Database analysis of children and adolescents with bipolar disorder consuming a micronutrient formula. Rucklidge JJ, Gately D, Kaplan BJ BMC Psychiatry 2010 Sep 28;10:74 Summary /  Full Text

Successful Treatment of Bipolar Disorder II and ADHD with a Micronutrient Formula: A Case Study. Rucklidge JJ, Harrison R CNS Spectrums 2010 May;15(5):289-95 Summary /  Full Text

Micronutrients versus standard medication management in autism: a naturalistic case-control study. Mehl-Madrona L, Leung B, Kennedy C, Paul S, Kaplan BJ Journal of Child and Adolescent Psychopharmacology 2010 Apr;20(2):95-103 Summary /  Full Text

Successful treatment of OCD with a micronutrient formula following partial response to Cognitive Behavioral Therapy (CBT): a case study. Rucklidge JJ Journal of Anxiety Disorders 2009 Aug;23(6):836-40 Summary /  Full Text

Multinutrient supplement as treatment: literature review and case report of a 12-year-old boy with bipolar disorder. Frazier EA, Fristad MA, Arnold LE Journal of Child and Adolescent Psychopharmacology 2009 Aug;19(4):453-60 Summary /  Full Text

Database analysis of adults with bipolar disorder consuming a micronutrient formula. Gately D, Kaplan BJ Clinical Medicine Insights: Psychiatry 2009 Apr;4:3-16 Summary /  Full Text

Improved mood and behavior during treatment with a mineral-vitamin supplement: an open-label case series of children. Kaplan BJ, Fisher JE, Crawford SG, Field CJ, Kolb B Journal of Child and Adolescent Psychopharmacology 2004 Spring;14(1):115-22 Summary /  Full Text

Nutritional approach to bipolar disorder. Simmons M Journal of Clinical Psychiatry 2003 Mar;64(3):338 Summary /  Full Text

Treatment of mood lability and explosive rage with minerals and vitamins: two case studies in children. Kaplan BJ, Crawford SG, Gardner B, Farrelly G Journal of Child and Adolescent Psychopharmacology 2002 Fall;12(3):205-19 Summary /  Full Text

Do vitamins or minerals (apart from lithium) have mood-stabilizing effects? Popper CW Journal of Clinical Psychiatry 2001 Dec;62(12):933-5 Summary /  Full Text

Effective mood stabilization with a chelated mineral supplement: an open-label trial in bipolar disorder. Kaplan BJ, Simpson JS, Ferre RC, Gorman CP, McMullen DM, Crawford SG Journal of Clinical Psychiatry 2001 Dec;62(12):936-44 Summary /  Full Text